Sparse root system slows establishment after transplanting.
Oddly enough, Missouri BG states that full sun actually make the fall color less reliable, which would be a first if true. In any case, full sun may bleach the leaves. Suggest combining with ericaceous plants.
Branches can famously be tied in knots. Fall color variable. No terminal buds(?!).
Fruits and roots are slightly toxic; bark may cause contact dermatitis.
Despite being native, leatherwood is listed by Doug Tallamy as supporting only one species of butterfly/moth larvae.
Sources: Stoecklein, Missouri BG, Dirr, NCSU, UConn.
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